Management of acute organophosphorus pesticide poisoning

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Management of acute organophosphorus pesticide poisoning

Organophosphorus pesticide self-poisoning is an important clinical problem in rural regions of the developing world, and kills an estimated 200,000 people every year. Unintentional poisoning kills far fewer people but is a problem in places where highly toxic organophosphorus pesticides are available. Medical management is difficult, with case fatality generally more than 15%. We describe the l...

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Management of severe organophosphorus pesticide poisoning

We read with interest the paper by Sungar and Güven [1], which described a case series of organophosphorus pesticide (OP)-poisoned patients managed in their intensive care unit. It clearly demonstrates the difficulty in managing such patients in resource-poor areas [2]. However, we should like to query some issues in their management of OP poisoning and their use of pralidoxime. We cannot under...

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Application of hemoperfusion in severe acute organophosphorus pesticide poisoning

Background/aim: The aim of this research is to investigate the clinical efficacy of hemoperfusion in the treatment of severe acute organophosphorus pesticide poisoning (AOPP). Materials and methods: Patients meeting the inclusion criteria were divided into Groups 1 and 2 according to whether hemoperfusion was applied or not. Group 2 was observed as the control group. Conventional therapy for AO...

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Therapeutic effects of HESA-A (a herbal-marine compound) in acute organophosphorus pesticide poisoning

Objective: Organophosphorus compounds (OPs) are common causes of poisonings. Atropine and oximes are pharmacological antidotes of OPs. However, because of their adverse effects and insufficient performance, several other compounds have been evaluated as adjuvant therapy. HESA-A is a herbal-marine drug that contains material from Carum carvi (Persian cumin), Penaeus latisculatus...

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Independent Prognostic Factors for Acute Organophosphorus Pesticide Poisoning.

BACKGROUND Acute organophosphorus pesticide poisoning (AOPP) is becoming a significant problem and a potential cause of human mortality because of the abuse of organophosphate compounds. This study aims to determine the independent prognostic factors of AOPP by using multivariate logistic regression analysis. METHODS The clinical data for 71 subjects with AOPP admitted to our hospital were re...

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ژورنال

عنوان ژورنال: The Lancet

سال: 2008

ISSN: 0140-6736

DOI: 10.1016/s0140-6736(08)60947-2